The last 18 months have been an injury hell for Kompany who has struggled to stay match fit for a sustained period of time.
Kompany returned to full fitness at the end of November, but was substituted after an hour against Manchester United on Sunday.
It is a worrying sight for City fans and Guardiola issued an injury update on the Belgian after the game.
He said: ‘Kompany is injured. We wait and see.
Manchester City 2017/18 Fixtures
Swansea City (A) – Wed Dec 13
Tottenham (H) – Sat Dec 16
Leicester City (A) – Tues Dec 19 (EFL Cup)
Bournemouth (H) – Sat Dec 23
Newcastle United (A) – Wed Dec 27
Crystal Palace (A) – Sun Dec 31
Watford (H) – Tues Jan 2
‘Vinny is always like this and we cannot count on him for a long time.’
City are already without John Stones at the back and with Kompany facing another spell on the sidelines it could mean a defensive crisis for the Premier League leaders.
Nicolas Otamendi and Eliaquim Mangala would be the only two fit senior centre-backs with a hectic Christmas schedule already underway.
More: Manchester City FC
City need to perform over Christmas to maintain their iron grip at the top of the table.
Eleven points separate them and second-place United, but Guardiola’s team cannot afford to take their foot off the gas pedal just yet.
A defensive injury crisis could prove costly for City who are so far unbeaten in the league this season.
City set a new winning-streak record in the English top flight by claiming their 14th league victory in a row.
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